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Exploring Atypical Antipsychotics as an Augmentation Option for Major Depressive Disorder

neuroscienceCME TV

Premiere Date: Wednesday, December 12, 2007

This activity offers CE credit for:

1. Physicians (ACCME/AMA PRA Category 1)
2. Nurses (CNE)
3. Pharmacists (ACPE)
4. Psychologists (APA)
5. Social Workers (NASW)
6. Certified Case Managers (CCMC)

All other clinicians will either receive a CME Attendance Certificate or may choose any of the types of CE credit being offered.
Credit Expiration Date:
Friday, December 12, 2008

Faculty

MODERATOR: Ned H. Kalin, MD Hedberg Professor and Chairman Department of Psychiatry The University of Wisconsin Medical School Director, HealthEmotions Research Institute Madison, WI

J. Alexander Bodkin, MD Assistant Professor of Psychiatry Harvard Medical School Director, Clinical Psychopharmacology Research Program McLean Hospital Boston, MA

Mark Hyman Rapaport, MD Chairman, Department of Psychiatry and Behavioral Neurosciences Cedars-Sinai Medical Center The Polier Endowed Chair in Schizophrenia and Related Disorders Vice Chairman and Professor in Residence David Geffen School of Medicine at UCLA Los Angeles, CA

Faculty Bios and Disclosure Declaration

Click here to view faculty bios and activity disclosures.

Statement of Need

Major depressive disorder is a debilitating affective disorder associated with significant morbidity and mortality. Numerous treatment options with varying mechanisms of action exist, but the biological heterogeneity of this condition often results in differential patient responses. Understanding the neurobiology of depression is critical to identifying optimal treatment strategies for each patient.

Although there are a variety of nonpharmacologic and pharmacologic treatment strategies, data from the NIMH-sponsored Sequenced Treatment Alternatives to Relieve Depression (STAR*D) indicate that only one-third of patients achieve remission with an initial therapy.(1) These findings illustrate the need for safe and effective alternate treatments that improve outcomes in patients with major depressive disorder. Atypical antipsychotics may represent an augmentation option for patients who fail to respond to traditional therapies. In this live, evidence-based neuroscienceCME TV activity, the experts will review the neurobiology of depression and remission rates for current therapies, and explore alternate strategies for the management of depression.

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1. Trivedi MH, Rush AJ, Wisniewski SR, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry 2006;163:28-40.

Activity Goal

To examine the neurobiology of depression, evaluate the effectiveness of traditional antidepressant medications, and explore atypical antipsychotics as an augmentation option for patients that do not remit with traditional antidepressant therapies.

Learning Objectives

At the end of this CE activity, participants should be able to:

• Summarize the neurobiological substrates of depression and the mechanisms of action of alternate pharmacologic strategies.
• Evaluate remission rates for standard antidepressant therapies used in the management of depression.
• Analyze the efficacy and safety of atypical antipsychotics as adjunctive therapy for the treatment of major depressive disorder.

Target Audience

Physicians, physician assistants, nurse practitioners, nurses, psychologists, social workers, certified case managers, pharmacists, and other healthcare professionals with an interest in mental health.

Financial Support

CME Outfitters, LLC, and CME LLC gratefully acknowledge an educational grant from Bristol-Myers Squibb Company and Otsuka America Pharmaceuticals, Inc., in support of this CE activity.

Credit Information

CME Credit (Physicians):
CME Outfitters, LLC, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CME Outfitters, LLC, designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Note to Physician Assistants: AAPA accepts Category I credit from AOACCME, Prescribed credit from AAFP, and AMA Category I CME credit for the PRA from organizations accredited by ACCME.

CNE Credit (Nurses):
CME Outfitters, LLC, is an approved provider of continuing nursing education by the New York State Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation.

It has been assigned code 6WASUP-PRV-0622. 1.0 contact hours will be awarded upon successful completion. This activity is co-provided with CME LLC.
Note to Nurse Practitioners: The content of this CNE activity pertains to Pharmacology.

CEP Credit (Psychologists):
CME Outfitters is approved by the American Psychological Association to sponsor continuing education for psychologists. CME Outfitters maintains responsibility for this program and its content. (1.0 CE credits)

NASW Credit (Social Workers):
This program was approved by the National Association of Social Workers (provider #886407722) for 1 continuing education contact hour.

CCMC Credit (Certified Case Managers):
This program has been approved for 1 hour by the Commission for Case Manager Certification (CCMC).

CPE Credit (Pharmacists):
CME Outfitters, LLC, is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. 1.0 contact hours (0.1 CEUs)
Universal Program Number: 376-999-07-022-L01-P (live presentation) 376-999-07-022-H01-P (recorded programs)

Post-tests, credit request forms, and activity evaluations can be completed online at www.neuroscienceCME.com (click on the Testing/Certification link under the Resources tab - requires free account activation), and participants can print their certificate or statement of credit immediately (70% pass rate required). Otherwise, participants should fully complete and return both the credit request form and activity evaluation located within the course guide for this activity. A certificate or statement of credit will be mailed within 4-6 weeks to all who successfully complete these requirements.

Questions about this activity? Call us at 877.CME.PROS (877.263.7767).