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Circadian Rhythms, Sleep, and Wellness: An Interactive Case Series

neuroscienceCME Webcast

Premiere Date: Monday, June 11, 2007

This activity offers CE credit for:

Physicians (ACCME/AMA PRA Category 1)
All other clinicians will receive a CME Attendance Certificate.

Credit Expiration Date:
Wednesday, June 11, 2008
Note: Credit Is No Longer Available

Faculty


Robert Moore, MD, PhDRobert Moore, MD, PhD 
Love Family Professor
Department of Neurology and Neuroscience
University of Pittsburgh
Pittsburgh, PA

Charles Czeisler, PhD, MDCharles Czeisler, PhD, MD 
Baldno Professor of Sleep Medicine; Director Division of Sleep Medicine
Harvard Medical School
Chief, Division of Sleep Medicine
Brigham and Women’s Hospital
Boston, MA

Jonathan R. Schwartz, MDJonathan R. Schwartz, MD 
Clinical Professor
Department of Medicine
University of Oklahoma Health Science Center
Medical Director
Integris Sleep Disorders Center of Oklahoma
Oklahoma City, OK

Eve Van Cauter, PhD 
Professor of Medicine
Committee on Molecular Metabolism and Nutrition
University of Chicago
Chicago, IL

Phyllis C. Zee, MD, PhDPhyllis C. Zee, MD, PhD 
Director, Center for Circadian and Sleep Medicine
Chief of Sleep Medicine in the Department of Neurology
Benjamin and Virginia T. Boshes Professor of Neurology
Professor of Neurology (Sleep Medicine)
Northwestern University Feinberg School of Medicine
Chicago, IL

Statement of Need

The role of chronobiology in sleep medicine is profound and pervasive, and the two disciplines have begun to move closer as basic research in circadian rhythms provides important insight into the biology of sleep and sleep disorders. The chronobiology of sleep focuses on rhythms such as the sleep-wake cycle, body temperature, hormonal cycles, and hibernation cycles. The human sleep-wake cycle is a complex process governed by two opposing processes: the homeostatic drive for sleep and the circadian system that regulates wakefulness.(1) Circadian rhythm disorders may arise from an inconsistency or misalignment between the body's internal circadian rhythm and external cues, such as light-dark exposure. Disruption of the sleep-wake cycle, as occurs with circadian rhythm disorders, may result in a broad range of interconnected pathologies, including poor vigilance and memory, reduced mental and physical reaction times, reduced motivation, depression, insomnia, metabolic abnormalities, cardiovascular abnormalities, obesity and even a greater risk of cancer.(2,3) The demands of a 24/7 culture have increasingly marginalized the importance of sleep and wakefulness for patients' physical and mental health.(3) Thus, it is imperative that clinicians understand the impact of circadian rhythm disruptions on overall health in order to help patients achieve a better balance between the opposing biologic drives for sleep and wakefulness. In this live and interactive case-based activity, the faculty experts will explore how circadian rhythm disturbances impact both patient health and society and will address management strategies for disturbances in circadian rhythmicity.


  1. Dijk D-J, Lockley SW. Integration of human sleep-wake regulation and circadian rhythmicity. J Appl Physiol 2002;92:852-862.
  2. Knuttson A. Health disorders of shift workers. Occupational Medicine 2003;53:103-108.
  3. Foster GR, Wulff K. The rhythm of rest and excess. Nat Rev Neurosci 2005;6:407-414.

Credit Requirements

Successful completion of this CME activity includes participating in the educational activity, reviewing the course materials, and following the appropriate set of instructions below by June 11, 2008:

Option A:
To complete your credit request form, activity evaluation, and post-test online (70% pass rate required), and print your certificate immediately, please visit www.neuroscienceCME.com and click on the Testing/Certification link under the Resources tab (requires free account activation).

Option B:
Complete the credit request form and activity evaluation located in the main menu under "Course Guide, Post-Test and CME Credit Forms." Successfully complete the post-test (70%) and record your responses on the credit request form.

Submit completed forms via FAX to 240.243.1033 or mail to:
CME Outfitters, LLC
2400 Research Boulevard, Suite 425
Rockville, MD 20850
Attention: CE Forms Processor

Participants will receive a certificate within 4-6 weeks following receipt of the credit request form and activity evaluation form.

Activity Goal

To provide case-based educational information and clinical context regarding the appropriate management options for patients with circadian rhythm disturbances.

Learning Objectives

At the end of this CE activity, participants should be able to:

  • Delineate the importance of chronobiology in sleep-wake disturbances and emphasize the practical application of this concept in patient care.
  • Recognize the personal and societal impact of sleep-wake disturbances associated with circadian rhythm disorders.
  • Identify clinical characteristics of circadian rhythm disorders and utilize appropriate nonpharmacologic and pharmacologic management strategies to enhance patient outcomes.

Target Audience

Physicians with an interest in sleep disorders.

Credit Information

CME Credit (Physicians):
CME Outfitters, LLC, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CME Outfitters, LLC, designates this educational activity for a maximum of 2.5 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Disclosure Declaration

All faculty participating in CME Outfitters continuing education activities are required to disclose any conflict(s) of interest related to the content of their presentation(s) as defined by the ACCME's Standards for Commercial Support, and other accrediting and regulatory bodies. Full disclosure of faculty relationships will be made on this website and within the activity course materials prior to the premiere date of this activity.

Questions about this activity? Call us at 877.CME.PROS (877.263.7767).

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