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Pharmacodynamics of Atypical Antipsychotics: Clinical Correlations and Practice Implications

neuroscienceCME TV

Premiere Date: Wednesday, August 22, 2007

This activity offers CE credit for:

1. Physicians (ACCME/AMA PRA Category 1)
2. Nurses (CNE)
3. Pharmacists (ACPE)
4. Psychologists (APA)
5. Social Workers (NASW)
6. Certified Case Managers (CCMC)

All other clinicians will either receive a CME Attendance Certificate or may choose any of the types of CE credit being offered.
Credit Expiration Date:
Friday, August 22, 2008

Faculty

Peter J. Weiden, MD  Director, Psychosis Program Center for Cognitive Medicine Department of Psychiatry University of Illinois at Chicago Chicago, IL

Christoph U. Correll, MD  Assistant Professor of Psychiatry and Behavioral Sciences Albert Einstein College of Medicine Director, Adverse Events Assessment and Prevention Unit The Zucker Hillside Hospital North Shore Glen Oaks, NY

Sheldon H. Preskorn, MD  President and Chief Executive Officer Clinical Research Institute Professor, Department of Psychiatry and Behavioral Sciences University of Kansas School of Medicine-Wichita Wichita, KS

Statement of Need

Understanding the pharmacodynamic principles of antipsychotic medications can be very helpful in guiding clinicians in certain key aspects of psychopharmacologic practice, including medication selection, dosing, and management of adverse events. Knowledge of these pharmacodynamic principles is particularly useful in guiding when and how to safely combine or change antipsychotic medication. Presenting the clinically salient aspects of antipsychotic pharmacodynamics involves understanding the concept of how these agents differentially affect the dopamine system, and the range of binding actions on other monoamine receptors besides the family of dopamine receptors. Clinicians need to be able to gauge how differences in dopamine and non-dopamine binding profiles can translate into important clinical effects, including the timing and likelihood of neurologic and other adverse events, interactions with patient-specific factors such as age, likelihood of withdrawal problems, and other issues related to common practices involving combining psychotropic medications. Understanding the pharmacology or drug disposition of atypical antipsychotic agents - including their absorption, distribution, metabolism, and elimination - is essential, as these characteristics impact dosing, drug-drug interactions, withdrawal effects, and eventually the efficacy and safety of these medications. Side effects can complicate and undermine antipsychotic treatment in various ways by causing or worsening symptoms associated with schizophrenia, including negative, positive, and cognitive symptoms as well as agitation. In this evidence-based neuroscienceCME TV activity, the experts discuss the clinical correlations and practice implications that can aid clinicians in utilizing basic concepts of pharmacodynamics and pharmacology to develop individualized treatment strategies to optimize both the mental and physical health of their patients.

Activity Goal

To utilize principles of pharmacology and pharmacodynamics to make individualized treatment decisions to help patients achieve better mental and physical health outcomes.

Learning Objectives

At the end of this CE activity, participants should be able to:

• Review the basic concepts of pharmacology and pharmacodynamics and their application in clinical practice.
• Recognize the clinical correlation between pharmacodynamic principles and adverse events, withdrawal effects, and drug-drug interactions of atypical antipsychotics.
• Apply principles of pharmacology to individualized treatment decisions to help patients achieve better mental and physical health outcomes.

Target Audience

Physicians, physician assistants, nurse practitioners, nurses, psychologists, social workers, case managers, pharmacists, and other clinicians with an interest in mental health.

Financial Support

CME Outfitters, LLC, and CME LLC gratefully acknowledge an educational grant from Bristol-Myers Squibb Company and Otsuka America Pharmaceuticals, Inc., in support of this CE activity.

Credit Information

CME Credit (Physicians):
CME Outfitters, LLC, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CME Outfitters, LLC, designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Note to Physician Assistants: AAPA accepts Category I credit from AOACCME, Prescribed credit from AAFP, and AMA Category I CME credit for the PRA from organizations accredited by ACCME.

CNE Credit (Nurses):
CME Outfitters, LLC, is an approved provider of continuing nursing education by the New York State Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation.

It has been assigned code 6WASUP-PRV-069. 1.0 contact hours will be awarded upon successful completion. This activity is co-provided with CME LLC.
Note to Nurse Practitioners: The content of this CNE activity pertains to Pharmacology.

CEP Credit (Psychologists):
CME Outfitters is approved by the American Psychological Association to sponsor continuing education for psychologists. CME Outfitters maintains responsibility for this program and its content. (1.0 CE credits)

NASW Credit (Social Workers):
This program was approved by the National Association of Social Workers (provider #886407722) for 1 continuing education contact hour.

CCMC Credit (Certified Case Managers):
This program has been approved for 1 hour by the Commission for Case Manager Certification (CCMC).

CPE Credit (Pharmacists):
CME Outfitters, LLC, is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. 1.0 contact hours (0.1 CEUs)
Universal Program Number: 376-999-07-011-L01 (live presentation) 376-999-07-011-H01 (recorded programs)

Post-tests, credit request forms, and activity evaluations can be completed online at www.neuroscienceCME.com (click on the Testing/Certification link under the Resources tab - requires free account activation), and participants can print their certificate or statement of credit immediately (70% pass rate required). Otherwise, participants should fully complete and return both the credit request form and activity evaluation located within the course guide for this activity. A certificate or statement of credit will be mailed within 4-6 weeks to all who successfully complete these requirements.

Disclosure Declaration

All faculty participating in CME Outfitters continuing education activities are required to disclose any conflict(s) of interest related to the content of their presentation(s) as defined by the ACCME's Standards for Commercial Support, and other accrediting and regulatory bodies. Full disclosure of faculty relationships will be made on this website and within the activity course materials prior to the premiere date of this activity.

Questions about this activity? Call us at 877.CME.PROS (877.263.7767).